Ongoing tiredness in some. One user, Susan, 58, noted initial drain.
7. Heartburn or Indigestion
Acid reflux-like feel post-meals.
6. Bloating or Gas
Common digestive shift. Extended-release may help.
5. Loss of Appetite
Reduced hunger, sometimes leading to weight changes.

4. Vomiting
Less frequent but disruptive if persistent.
3. Vitamin B12 Deficiency
Long-term use may lower levels, causing tiredness or numbness. Monitoring suggested.
2. Diarrhea
Frequent early on. Often improves with time or dose tweaks.
1. Nausea & Stomach Upset
Top reported—up to 25% experience. Like Maria, 62, who found relief taking with food. But wait, a rare serious one lurks.
Bonus Serious Mention: Lactic Acidosis
Rare but critical—symptoms like muscle pain, breathing issues need urgent care.